THE SELFISH BRAIN THEORY
Selfish-Brain
The Selfish Brain Clinical Research Group
www.selfish-brain.net 
Recent Publications:
Achim Peters, Professor of Internal Medicine, Endocrinology
Medical Clinic I, University of Luebeck, Germany

  1. Peters A, Conrad M, Hubold C, Schweiger U, Fischer B, Fehm HL 2007 The principle of homeostasis in the hypothalamus-pituitary-adrenal system: new insight from positive feedback. Am J Physiol Regul Integr Comp Physiol 293:R83-R98

  2. Schweiger U, Greggersen W, Rudolf S, Pusch M, Menzel T, Winn S, Hassfurth J, Fassbinder E, Kahl KG, Oltmanns KM, Hohagen F, Peters A 2008 Disturbed glucose disposal in patients with major depression; application of the glucose clamp technique. Psychosom Med 70:170-176

  3. Oltmanns KM, Melchert UH, Scholand-Engler HG, Schultes B, Schweiger U, Peters A 2008 Divergent effects of hyper- and hypoglycemia on circulating vascular endothelial growth factor in humans. Metabolism 57:90-94

  4. Oltmanns KM, Melchert UH, Scholand-Engler HG, Howitz MC, Schultes B, Schweiger U, Hohagen F, Born J, Peters A, Pellerin L 2008Differential energetic response of brain vs. skeletal muscle upon glycemic variations in healthy humans. Am J Physiol Regul Integr Comp Physiol 294:R12-R16

  5. Jauch-Chara K, Hallschmid M, Gais S, Oltmanns KM, Peters A, Born J, Schultes B 2007 Awakening and counterregulatory response to hypoglycemia during early and late sleep. Diabetes 56:1938-1942

  6. Ludwig AK, Weiss JM, Tauchert S, Dietze T, Rudolf S, Diedrich K, Peters A, Oltmanns KM 2007 Influence of hypo- and hyperglycaemia on plasma leptin concentrations in healthy women and in women with polycystic ovary syndrome. Hum Reprod 22:1555-1561

  7. Jauch-Chara K, Hallschmid M, Schmid SM, Oltmanns KM, Peters A, Born J, Schultes B 2007 Plasma glucagon decreases during night-time sleep in Type 1 diabetic patients and healthy control subjects. Diabet Med 24:684-687

  8. Schultes B, Jauch-Chara K, Gais S, Hallschmid M, Reiprich E, Kern W, Oltmanns KM, Peters A, Fehm HL, Born J 2007Defective awakening response to nocturnal hypoglycemia in patients with type 1 diabetes mellitus. PLoS Med 4:e69

  9. Pais I, Hallschmid M, Jauch-Chara K, Schmid SM, Oltmanns KM, Peters A, Born J, Schultes B 2007 Mood and cognitive functions during acute euglycaemia and mild hyperglycaemia in type 2 diabetic patients. Exp Clin Endocrinol Diabetes 115:42-46

  10. Peters A, Pellerin L, Dallman MF, Oltmanns KM, Schweiger U, Born J, Fehm HL 2007 Causes of obesity: looking beyond the hypothalamus. Prog Neurobiol 81:61-88

  11. Peters A, Lehnert H 2007 [Metabolic syndrome. Origin within the central nervous system?]. Internist (Berl) 48:134-143

  12. Peters A 2006 The energy request of inflammation. Endocrinology 147:4550-4552

  13. Fehm HL, Kern W, Peters A 2006 The selfish brain: competition for energy resources. Prog Brain Res 153:129-140

  14. Oltmanns KM, Gehring H, Rudolf S, Schultes B, Schweiger U, Born J, Fehm HL, Peters A 2006 Persistent suppression of resting energy expenditure after acute hypoxia. Metabolism 55:669-675

  15. Hubold C, Oltmanns KM, Schultes B, Jelkmann W, Born J, Fehm HL, Schweiger U, Peters A 2006 High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetes. Int J Obes (Lond) 30:1356-1361

  16. Fehm HL, Peters A 2007 [Role of the hippocampus in obesity and metabolic syndrome]. Nervenarzt 78:584-585

  17. Oltmanns KM, Dodt B, Schultes B, Raspe HH, Schweiger U, Born J, Fehm HL, Peters A 2006 Cortisol correlates with metabolic disturbances in a population study of type 2 diabetic patients. Eur J Endocrinol 154:325-331

  18. Schultes B, Schmid S, Peters A, Born J, Fehm HL 2005 Sleep loss and the development of diabetes: a review of current evidence. Exp Clin Endocrinol Diabetes 113:563-567

  19. Schultes B, Peters A, Hallschmid M, Benedict C, Merl V, Oltmanns KM, Born J, Fehm HL, Kern W 2005 Modulation of food intake by glucose in patients with type 2 diabetes. Diabetes Care 28:2884-2889

  20. Bahlmann L, Oltmanns KM, Peters A, Poeling J, Schwemmer U, Heringlake M, Klaus S 2005 Metabolic stress during hypoglycaemia clamp assessed by microdialysis. Minerva Anestesiol 71:711-716

  21. Oltmanns KM, Gehring H, Rudolf S, Schultes B, Hackenberg C, Schweiger U, Born J, Fehm HL, Peters A 2006 Acute hypoxia decreases plasma VEGF concentration in healthy humans. Am J Physiol Endocrinol Metab 290:E434-E439

  22. Merl V, Peters A, Oltmanns KM, Kern W, Born J, Fehm HL, Schultes B 2005 Serum adiponectin concentrations during a 72-hour fast in over- and normal-weight humans. Int J Obes (Lond) 29:998-1001

  23. Oltmanns KM, Fehm HL, Peters A 2005 Chronic fentanyl application induces adrenocortical insufficiency. J Intern Med 257:478-480

  24. Kern W, Peters A, Born J, Fehm HL, Schultes B 2005 Changes in blood pressure and plasma catecholamine levels during prolonged hyperinsulinemia. Metabolism 54:391-396

  25. Schultes B, Peters A, Kern W, Gais S, Oltmanns KM, Fehm HL, Born J 2005 Processing of food stimuli is selectively enhanced during insulin-induced hypoglycemia in healthy men. Psychoneuroendocrinology 30:496-504

  26. Oltmanns KM, Peters A, Kern W, Fehm HL, Born J, Schultes B 2005 Preserved inhibitory effect of recurrent hypoglycaemia on the male gonadotrophic axis. Clin Endocrinol (Oxf) 62:217-222

  27. Merl V, Peters A, Oltmanns KM, Kern W, Hubold C, Hallschmid M, Born J, Fehm HL, Schultes B 2004 Preserved circadian rhythm of serum insulin concentration at low plasma glucose during fasting in lean and overweight humans. Metabolism 53:1449-1453

  28. Schultes B, Kern W, Oltmanns K, Peters A, Gais S, Fehm HL, Born J 2005 Differential adaptation of neurocognitive brain functions to recurrent hypoglycemia in healthy men. Psychoneuroendocrinology 30:149-161

  29. Merl V, Kern W, Peters A, Oltmanns KM, Gais S, Born J, Fehm HL, Schultes B 2004 Differences between nighttime and daytime hypoglycemia counterregulation in healthy humans. Metabolism 53:894-898

  30. Fehm HL, Born J, Peters A 2004 Glucocorticoids and melanocortins in the regulation of body weight in humans. Horm Metab Res 36:360-364

  31. Peters A, Schweiger U, Pellerin L, Hubold C, Oltmanns KM, Conrad M, Schultes B, Born J, Fehm HL 2004 The selfish brain: competition for energy resources. Neurosci Biobehav Rev 28:143-180

  32. Oltmanns KM, Gehring H, Rudolf S, Schultes B, Rook S, Schweiger U, Born J, Fehm HL, Peters A 2004 Hypoxia causes glucose intolerance in humans. Am J Respir Crit Care Med 169:1231-1237

  33. Oltmanns KM, Deininger E, Wellhoener P, Schultes B, Kern W, Marx E, Dominiak P, Born J, Fehm HL, Peters A 2003 Influence of captopril on symptomatic and hormonal responses to hypoglycaemia in humans. Br J Clin Pharmacol 55:347-353

  34. Schultes B, Oltmanns KM, Kern W, Fehm HL, Born J, Peters A 2003 Modulation of hunger by plasma glucose and metformin. J Clin Endocrinol Metab 88:1133-1141

  35. Gais S, Born J, Peters A, Schultes B, Heindl B, Fehm HL, Werner K 2003 Hypoglycemia counterregulation during sleep. Sleep 26:55-59

  36. Schultes B, Oltmanns KM, Kern W, Born J, Fehm HL, Peters A 2002 Acute and prolonged effects of insulin-induced hypoglycemia on the pituitary-thyroid axis in humans. Metabolism 51:1370-1374

  37. Peters A, Schweiger U, Fruhwald-Schultes B, Born J, Fehm HL 2002 The neuroendocrine control of glucose allocation. Exp Clin Endocrinol Diabetes 110:199-211

  38. Fruehwald-Schultes B, Oltmanns KM, Kern W, Born J, Fehm HL, Peters A 2002 The effect of experimentally induced insulin resistance on the leptin response to hyperinsulinaemia. Int J Obes Relat Metab Disord 26:510-516

  39. Fruehwald-Schultes B, Oltmanns KM, Toschek B, Sopke S, Kern W, Born J, Fehm HL, Peters A 2002 Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men. Metabolism 51:531-536

  40. Dantz D, Bewersdorf J, Fruehwald-Schultes B, Kern W, Jelkmann W, Born J, Fehm HL, Peters A 2002 Vascular endothelial growth factor: a novel endocrine defensive response to hypoglycemia. J Clin Endocrinol Metab 87:835-840

  41. Deininger E, Oltmanns KM, Wellhoener P, Fruehwald-Schultes B, Kern W, Heuer B, Dominiak P, Born J, Fehm HL, Peters A 2001 Losartan attenuates symptomatic and hormonal responses to hypoglycemia in humans. Clin Pharmacol Ther 70:362-369

  42. Oltmanns KM, Fruehwald-Schultes B, Kern W, Born J, Fehm HL, Peters A 2001 Hypoglycemia, but not insulin, acutely decreases LH and T secretion in men. J Clin Endocrinol Metab 86:4913-4919

  43. Kern W, Peters A, Fruehwald-Schultes B, Deininger E, Born J, Fehm HL 2001 Improving influence of insulin on cognitive functions in humans. Neuroendocrinology 74:270-280

  44. Fruehwald-Schultes B, Kern W, Oltmanns KM, Sopke S, Toschek B, Born J, Fehm HL, Peters A 2001Metformin does not adversely affect hormonal and symptomatic responses to recurrent hypoglycemia. J Clin Endocrinol Metab 86:4187-4192

  45. Fruehwald-Schultes B, Kern W, Born J, Fehm HL, Peters A 2001 Hyperinsulinemia causes activation of the hypothalamus-pituitary-adrenal axis in humans. Int J Obes Relat Metab Disord 25 Suppl 1:S38-S40

  46. Fruehwald-Schultes B, Born J, Kern W, Peters A, Fehm HL 2000 Adaptation of cognitive function to hypoglycemia in healthy men. Diabetes Care 23:1059-1066

  47. Fruehwald-Schultes B, Kern W, Born J, Fehm HL, Peters A 2000 Comparison of the inhibitory effect of insulin and hypoglycemia on insulin secretion in humans. Metabolism 49:950-953

  48. Peters A, Ehlers M, Blank B, Exler D, Falk C, Kohlmann T, Fruehwald-Schultes B, Wellhoener P, Kerner W, Fehm HL 2000Excess triiodothyronine as a risk factor of coronary events. Arch Intern Med 160:1993-1999

  49. Fruehwald-Schultes B, Kern W, Dantz D, Born J, Fehm HL, Peters A 2000 Preserved hypothermic response to hypoglycemia after antecedent hypoglycemia. Metabolism 49:794-798

  50. Wellhoener P, Fruehwald-Schultes B, Kern W, Dantz D, Kerner W, Born J, Fehm HL, Peters A 2000Glucose metabolism rather than insulin is a main determinant of leptin secretion in humans. J Clin Endocrinol Metab 85:1267-1271

  51. Fruehwald-Schultes B, Kern W, Beyer J, Forst T, Pfutzner A, Peters A 1999 Elevated serum leptin concentrations in type 2 diabetic patients with microalbuminuria and macroalbuminuria. Metabolism 48:1290-1293

  52. Fruehwald-Schultes B, Kern W, Bong W, Wellhoener P, Kerner W, Born J, Fehm HL, Peters A 1999 Supraphysiological hyperinsulinemia acutely increases hypothalamic-pituitary-adrenal secretory activity in humans. J Clin Endocrinol Metab 84:3041-3046

  53. Fruehwald-Schultes B, Peters A, Kern W, Beyer J, Pfutzner A 1999 Serum leptin is associated with serum uric acid concentrations in humans. Metabolism 48:677-680

  54. Fruehwald-Schultes B, Kern W, Deininger E, Wellhoener P, Kerner W, Born J, Fehm HL, Peters A 1999 Protective effect of insulin against hypoglycemia-associated counterregulatory failure. J Clin Endocrinol Metab 84:1551-1557

  55. Peters A, Rohloff D, Kohlmann T, Renner F, Jantschek G, Kerner W, Fehm HL 1998 Fetal hemoglobin in starvation ketosis of young women. Blood 91:691-694