THE SELFISH BRAIN THEORY
The Selfish Brain Clinical Research Group
www.selfish-brain.net 
Publications since 2000:
Horst Lorenz Fehm , Professor of Internal Medicine, Endocrinology
Medical Clinic I, University of Luebeck, Germany

  1. Dimitrov S, Lange T, Fehm HL, Born J 2004 A regulatory role of prolactin, growth hormone, and corticosteroids for human T-cell production of cytokines. Brain Behav Immun 18:368-374

  2. Dimitrov S, Lange T, Tieken S, Fehm HL, Born J 2004 Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans. Brain Behav Immun 18:341-348

  3. Fehm HL, Born J, Peters A 2004 Glucocorticoids and melanocortins in the regulation of body weight in humans. Horm Metab Res 36:360-364

  4. Merl V, Kern W, Peters A, Oltmanns KM, Gais S, Born J, Fehm HL, Schultes B 2004 Differences between nighttime and daytime hypoglycemia counterregulation in healthy humans. Metabolism 53:894-898

  5. Oltmanns KM, Gehring H, Rudolf S, Schultes B, Rook S, Schweiger U, Born J, Fehm HL, Peters A 2004 Hypoxia causes glucose intolerance in humans. Am J Respir Crit Care Med 169:1231-1237

  6. Peters A, Schweiger U, Pellerin L, Hubold C, Oltmanns KM, Conrad M, Schultes B, Born J, Fehm HL 2004 The selfish brain: competition for energy resources. Neurosci Biobehav Rev 28:143-180

  7. Schultes B, Fehm HL 2004 [Circadian rhythms in endocrinology]. Internist (Berl)

  8. Weitz G, Fehm HL, Dodt C 2004 Low birth weight and increased sympathetic activity. Circulation 109:e30

  9. Dodt C, Lonnroth P, Wellhoner JP, Fehm HL, Elam M 2003 Sympathetic control of white adipose tissue in lean and obese humans. Acta Physiol Scand 177:351-357

  10. Fischer S, Smolnik R, Herms M, Born J, Fehm HL 2003 Melatonin acutely improves the neuroendocrine architecture of sleep in blind individuals. J Clin Endocrinol Metab 88:5315-5320

  11. Gais S, Born J, Peters A, Schultes B, Heindl B, Fehm HL, Werner K 2003 Hypoglycemia counterregulation during sleep. Sleep 26:55-59

  12. Krug R, Molle M, Dodt C, Fehm HL, Born J 2003 Acute influences of estrogen and testosterone on divergent and convergent thinking in postmenopausal women. Neuropsychopharmacology 28:1538-1545

  13. Lange T, Perras B, Fehm HL, Born J 2003 Sleep enhances the human antibody response to hepatitis A vaccination. Psychosom Med 65:831-835

  14. Oltmanns KM, Deininger E, Wellhoener P, Schultes B, Kern W, Marx E, Dominiak P, Born J, Fehm HL, Peters A 2003 Influence of captopril on symptomatic and hormonal responses to hypoglycaemia in humans. Br J Clin Pharmacol 55:347-353

  15. Perras B, Wagner U, Born J, Fehm HL 2003 Improvement of sleep and pituitary-adrenal inhibition after subchronic intranasal vasopressin treatment in elderly humans. J Clin Psychopharmacol 23:35-44

  16. Schultes B, Oltmanns KM, Kern W, Fehm HL, Born J, Peters A 2003 Modulation of hunger by plasma glucose and metformin. J Clin Endocrinol Metab 88:1133-1141

  17. Born J, Lange T, Kern W, McGregor GP, Bickel U, Fehm HL 2002 Sniffing neuropeptides: a transnasal approach to the human brain. Nat Neurosci 5:514-516

  18. Dantz D, Bewersdorf J, Fruehwald-Schultes B, Kern W, Jelkmann W, Born J, Fehm HL, Peters A 2002 Vascular endothelial growth factor: a novel endocrine defensive response to hypoglycemia. J Clin Endocrinol Metab 87:835-840

  19. Fruehwald-Schultes B, Oltmanns KM, Toschek B, Sopke S, Kern W, Born J, Fehm HL, Peters A 2002 Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men. Metabolism 51:531-536

  20. Fruehwald-Schultes B, Oltmanns KM, Kern W, Born J, Fehm HL, Peters A 2002 The effect of experimentally induced insulin resistance on the leptin response to hyperinsulinaemia. Int J Obes Relat Metab Disord 26:510-516

  21. Lange T, Marshall L, Spath-Schwalbe E, Fehm HL, Born J 2002 Systemic immune parameters and sleep after ultra-low dose administration of IL-2 in healthy men. Brain Behav Immun 16:663-674

  22. Molle M, Marshall L, Fehm HL, Born J 2002 EEG theta synchronization conjoined with alpha desynchronization indicate intentional encoding. Eur J Neurosci 15:923-928

  23. Perras B, Petersen D, Lorch H, Fehm HL 2002 Psychoneuroendocrine disturbances in a patient with a rare granulomatous disease. Exp Clin Endocrinol Diabetes 110:248-252

  24. Perras B, Schultes B, Schwaiger R, Metz C, Wesseler W, Born J, Fehm HL 2002 Growth hormone-releasing hormone facilitates hypoglycemia-induced release of cortisol. Regul Pept 110:85-91

  25. Peters A, Schweiger U, Fruhwald-Schultes B, Born J, Fehm HL 2002 The neuroendocrine control of glucose allocation. Exp Clin Endocrinol Diabetes 110:199-211

  26. Pietrowsky R, Krug R, Fehm HL, Born J 2002 Food deprivation fails to affect preoccupation with thoughts of food in anorectic patients. Br J Clin Psychol 41:321-326

  27. Schultes B, Oltmanns KM, Kern W, Born J, Fehm HL, Peters A 2002 Acute and prolonged effects of insulin-induced hypoglycemia on the pituitary-thyroid axis in humans. Metabolism 51:1370-1374

  28. Deininger E, Oltmanns KM, Wellhoener P, Fruehwald-Schultes B, Kern W, Heuer B, Dominiak P, Born J, Fehm HL, Peters A 2001 Losartan attenuates symptomatic and hormonal responses to hypoglycemia in humans. Clin Pharmacol Ther 70:362-369

  29. Dodt C, Fehm HL, Weitz G 2001 Effect of estrogen replacement therapy on sympathetic activity in postmenopausal women. Circulation 104:E161-E162

  30. Fehm HL, Smolnik R, Kern W, McGregor GP, Bickel U, Born J 2001 The melanocortin melanocyte-stimulating hormone/adrenocorticotropin(4-10) decreases body fat in humans. J Clin Endocrinol Metab 86:1144-1148

  31. Fruehwald-Schultes B, Kern W, Oltmanns KM, Sopke S, Toschek B, Born J, Fehm HL, Peters A 2001 Metformin does not adversely affect hormonal and symptomatic responses to recurrent hypoglycemia. J Clin Endocrinol Metab 86:4187-4192

  32. Fruehwald-Schultes B, Kern W, Born J, Fehm HL, Peters A 2001 Hyperinsulinemia causes activation of the hypothalamus-pituitary-adrenal axis in humans. Int J Obes Relat Metab Disord 25 Suppl 1:S38-S40

  33. Hallschmid M, Molle M, Wagner U, Fehm HL, Born J 2001 Drinking related direct current positive potential shift in the human EEG depends on thirst. Neurosci Lett 311:173-176

  34. Kern W, Peters A, Fruehwald-Schultes B, Deininger E, Born J, Fehm HL 2001 Improving influence of insulin on cognitive functions in humans. Neuroendocrinology 74:270-280

  35. Klein J, Kern W, Fehm HL 2001 Fatigue and hyponatremia in a 75-year-old woman: unusual presentation of hypophysitis. Exp Clin Endocrinol Diabetes 109:120-123

  36. Marshall L, Perras B, Fehm HL, Born J 2001 Changes in immune cell counts and interleukin (IL)-1beta production in humans after a somnogenically active growth hormone-releasing hormone (GHRH) administration. Brain Behav Immun 15:227-234

  37. Oltmanns KM, Fruehwald-Schultes B, Kern W, Born J, Fehm HL, Peters A 2001 Hypoglycemia, but not insulin, acutely decreases LH and T secretion in men. J Clin Endocrinol Metab 86:4913-4919

  38. Perras B, Smolnik R, Fehm HL, Born J 2001 Signs of sexual behaviour are not increased after subchronic treatment with LHRH in young men. Psychoneuroendocrinology 26:1-15

  39. Pietrowsky R, Claassen L, Frercks H, Fehm HL, Born J 2001 Time course of intranasally administered cholecystokinin-8 on central nervous effects. Neuropsychobiology 43:254-259

  40. Weitz G, Elam M, Born J, Fehm HL, Dodt C 2001 Postmenopausal estrogen administration suppresses muscle sympathetic nerve activity. J Clin Endocrinol Metab 86:344-348

  41. Bierwolf C, Kern W, Molle M, Born J, Fehm HL 2000 Rhythms of pituitary-adrenal activity during sleep in patients with Cushing's disease. Exp Clin Endocrinol Diabetes 108:470-479

  42. Born J, Fehm HL 2000 The neuroendocrine recovery function of sleep. Noise Health 2:25-38

  43. Dodt C, Keyser B, Molle M, Fehm HL, Elam M 2000 Acute suppression of muscle sympathetic nerve activity by hydrocortisone in humans. Hypertension 35:758-763

  44. Dodt C, Lonnroth P, Fehm HL, Elam M 2000 The subcutaneous lipolytic response to regional neural stimulation is reduced in obese women. Diabetes 49:1875-1879

  45. Fehm HL, Perras B, Smolnik R, Kern W, Born J 2000 Manipulating neuropeptidergic pathways in humans: a novel approach to neuropharmacology? Eur J Pharmacol 405:43-54

  46. Fruehwald-Schultes B, Kern W, Dantz D, Born J, Fehm HL, Peters A 2000 Preserved hypothermic response to hypoglycemia after antecedent hypoglycemia. Metabolism 49:794-798

  47. Fruehwald-Schultes B, Kern W, Born J, Fehm HL, Peters A 2000 Comparison of the inhibitory effect of insulin and hypoglycemia on insulin secretion in humans. Metabolism 49:950-953

  48. Fruehwald-Schultes B, Born J, Kern W, Peters A, Fehm HL 2000 Adaptation of cognitive function to hypoglycemia in healthy men. Diabetes Care 23:1059-1066

  49. Kern W, Fittje A, Fohr W, Kerner W, Born J, Fehm HL 2000 Increase in systolic blood pressure and catecholamine level during hyperinsulinemia in a placebo-controlled euglycemic clamp in healthy subjects. Exp Clin Endocrinol Diabetes 108:498-505

  50. Klein HH, Muller R, Drenckhan M, Schutt M, Batge B, Fehm HL 2000 Insulin activation of insulin receptor kinase in erythrocytes is not altered in non-insulin-dependent diabetes and not influenced by hyperglycemia. J Endocrinol 166:275-281

  51. Krug R, Plihal W, Fehm HL, Born J 2000 Selective influence of the menstrual cycle on perception of stimuli with reproductive significance: an event-related potential study. Psychophysiology 37:111-122

  52. Marshall L, Molle M, Fehm HL, Born J 2000 Changes in direct current (DC) potentials and infra-slow EEG oscillations at the onset of the luteinizing hormone (LH) pulse. Eur J Neurosci 12:3935-3943

  53. Peters A, Ehlers M, Blank B, Exler D, Falk C, Kohlmann T, Fruehwald-Schultes B, Wellhoener P, Kerner W, Fehm HL 2000 Excess triiodothyronine as a risk factor of coronary events. Arch Intern Med 160:1993-1999

  54. Smolnik R, Perras B, Molle M, Fehm HL, Born J 2000 Event-related brain potentials and working memory function in healthy humans after single-dose and prolonged intranasal administration of adrenocorticotropin 4-10 and desacetyl-alpha-melanocyte stimulating hormone. J Clin Psychopharmacol 20:445-454

  55. Spath-Schwalbe E, Lange T, Perras B, Fehm HL, Born J 2000 Interferon-alpha acutely impairs sleep in healthy humans. Cytokine 12:518-521

  56. Wellhoener P, Fruehwald-Schultes B, Kern W, Dantz D, Kerner W, Born J, Fehm HL, Peters A 2000 Glucose metabolism rather than insulin is a main determinant of leptin secretion in humans. J Clin Endocrinol Metab 85:1267-1271