The Selfish Brain Clinical Research Group 
Recent Publications:
Fritz Hohagen, Professor of Psychiatry and Psychotherapy
Clinic of Psychiatry and Psychotherapy, University of Luebeck, Germany

  1. DYKIEREK, P., STADTMÜLLER, G., SCHRAMM, P., BAHRO, M., VAN CALKER, D., BRAUS, D. F., STEIGLEIDER, P., LÖW, H., HOHAGEN, F., GATTAZ, W.F., BERGER, M., RIEMANN, D (1998) The value of REM sleep parameters in differentiating Alzheimer’s disease from old-age depression and normal aging. Journ Psychiat Res, 32, 1-9

  2. GANN, H., FAULMANN, A., KIEMEN, A., KLEIN, T., EBERT, D., BACKHAUS, J., HORNYAK, M., VODERHOLZER, U., HOHAGEN, F., BERGER, M., RIEMANN, D.: Sleep and the Cholinergic REM Sleep Induction Test in Patients with Primary Alcoholism. Sleep Res Online, 1, 1998

  3. HOHAGEN, F., WINKELMANN, G., RASCHE-RÄUCHLE, H., KÖNIG, A., MÜNCHAU, N., GEIGER-KABISCH, C., SCHRAMM, P., REY, E., ALDENHOFF, J., HAND, I., BERGER, M.: Combination of behavior therapy with fluvoxamine in comparison to behavior therapy and placebo -results of a multicenter study. Br J Psych, 173 (suppl. 35), 71-78, 1998

  4. HOHAGEN, F., BERGER, M.: New perspectives in research and treatment of obsessive- compulsive disorder. Br J Psychiatry, 173 (suppl. 35) 1-6, 1998

  5. HORNYAK, M., VODERHOLZER, U., HOHAGEN, F., BERGER, M., RIEMANN, D.: Magnesium therapy for periodic leg movements related insomnia and restless legs syndrome. An open pilot study. Sleep, 21, 501-505, 1998

  6. SCHMIDTKE, K., SCHORB, A., WINKELMANN, G., HOHAGEN, F.: Cognitive Frontal Lobe Dysfunction in Obsessive-Compulsive Disorder. Biol Psychiatry, 43, 666-673, 1998

  7. VODERHOLZER, U., HORNYAK, M., THIEL, B., HUWIG-POPPE, C., KIEMEN, A., KÖNIG, A., BACKHAUS, J., RIEMANN, D., BERGER, M., HOHAGEN, F.: Impact of Experimentally Induced Serotonin Deficiency by Tryptophan Depletion on Sleep EEG in Healthy Subjects. Neuropsychopharmacology, 18, 112-124, 1998

  8. VODERHOLZER, U., BACKHAUS, J., HORNYAK, M., HOHAGEN, F., BERGER, M., RIEMANN, D.: A 19-h spontaneous sleep period in idiopathic central nervous system hypersomnia. J Sleep Res, 7, 101-103, 1998

  9. FEIGE; B., VODERHOLZER; U., RIEMANN, D., HOHAGEN, F., BERGER, M.,: Independent sleep EEG-slow-wave and spindle band dynamics associated with 4 weeks of continous application of short-half-life hypnotics in healthy subjects. Clinical Neurophysiology, 110, 1965-1974, 1999

  10. HOHAGEN, F.: Cognitive-Behavioral Therapy and Integrated Approaches in the Treatment of Obsessive-Compulsive Disorder. CNS-Spectrums 4, 35-40, 1999

  11. HUWIG-POPPE, CH., VODERHOLZER, U., BACKHAUS, J., RIEMANN, D., KÖNIG, A., HOHAGEN, F.: The Tryptophan Depletion Test. Impact on Sleep in Healthy Subjects and Patients with Obsessive-Compulsive Disorder. In: Hüther, G., Kochen, W., Simat, Th., Steinhart, H. (Hrsg.): Tryptophan, Serotonin and Melatonin. Basic Aspects and Applications. Kluwer Academic New York, Boston, Dordrecht, London, 35-42, 1999

  12. KÖNIG, A., THIEL, T., EBERT, D., OVERMEIER, S., HENKE, M., BERGER, M., HENNIG, J., HOHAGEN, F.: 1H Magnetic Resonance Spectroscopy of the Right Striatum in Obsessive-Compulsive Disorder: the Role of the Basal Ganglia. German Journal of Psychiatry 1999

  13. RIEMANN, D., KÖNIG, A., HOHAGEN, F., KIEMEN, A., VODERHOLZER, U., BACKHAUS, J., BUNZ, J., WESIACK, B., HERMLE, L., BERGER. M.: How to preserve the antidepressive effect of sleep deprivation: A comparison of sleep phase advance and sleep phase delay. Eur. Arch. Psychiatry Clin. Neurosci. 249, 231-237, 1999

  14. HOHAGEN, F.: Cognitive-Behavioural Therapy and Integrated Approaches in the Treatment of Obsessive-Compulsive Disorder. In: Maj, M., Sartorius, N., Okasha, A., Zohar, J. (Eds.): Obsessive-Compulsive Disorder. Wiley- & Sons Ltd. Chichester, New York, 136-139, 2000

  15. BERGER, M., VODERHOLZER, U., HOHAGEN, F.: Obsessive-Compulsive Disorder: an Underestimated Disorder. In: Maj, M., Sartorius, N., Okasha, A., Zohar, J. (Eds.): Obsessive-Compulsive Disorder. Wiley- & Sons Ltd. Chichester, New York, 297-299, 2000

  16. KORDON, A., HOHAGEN, F.: Neurobiologische Aspekte zur Ätiologie und Pathophysiologie der Zwangsstörung. Psychotherapie, Psychosomatik, Medizinische Psychologie 50, 428-434, 2000

  17. BACKHAUS, J., JUNGHANNS, K., HAJAK, G., MÜLLER-POPKES, K., RIEMANN, D., HOHAGEN, F.: Efficacy of training in sleep medicine for general practitioners in the diagnosis and treatment of insomnia: a preliminary report. In: Proceedings. New developments in the treatment of insomnia – Do they really have any impact on the primary health care setting? Kongreßband Third International WFRS Congress Dresden 1999 Medical Forum International, 38-47, 2001

  18. BACKHAUS, J., HOHAGEN, F., VODERHOLZER, U., RIEMANN, D.: Long-term effectiveness of a short-term cognitive-behavioural group treatment for primary insomnia Eur Arch Psychiatry Clin Neurosci 251, 35-41, 2001

  19. VODERHOLZER, U., RIEMANN, D., HORNYAK, M., BACKHAUS, J., FEIGE, B., BERGER, M., HOHAGEN, F.: A double-blind, randomized and placebo-controlled study on the polysomnographic withdrawal effects of zopiclone, zolpidem and triazolam in healthy studies. Eur Arch Psychiatry Clin Neurosci 251, 117-123, 2001

  20. VODERHOLZER, U., HOHAGEN, F., HERR, A., SUCK, A., KLEIN, T., HARTER, C., FIEBICH, B., RIEMANN, D.: Effects of Sleep Deprivation on Cytokines in Healthy and Depressed Subjects. In: Sperner-Unterweger, B., Fleischhacker, W.W., Kaschka, W.P. (eds.): Psychoneuroimmunology. Hypotheses and Current Research. Adv. Biol. Psychiatry Vol. 20. Karger: Basel, 98-109, 2001

  21. GANN, H., FEIGE, B., HOHAGEN, F., V.CALKER, D., GEISS, D., RIEMANN, D.: Sleep and the Cholinergic Rapid Eye Movement Sleep Induction Test in Patients with Primary Alcohol Dependence. Biological Psychiatry 50, 383-390, 2001

  22. RIEMANN, D., FEIGE, B., HORNYAK, M., KOCH, S., HOHAGEN, F., VODERHOLZER, U.: The tryptophan depletion test: impact on sleep in primary insomnia – a pilot study. Psychiatry Research 109, 129–135, 2002

  23. BACKHAUS, J., JUNGHANNS, K., MUELLER-POPKES, K., BROOCKS, A., RIEMANN, D., HAJAK, G., HOHAGEN, F.: Short-term training increases diagnostic and treatment rate for insomnia in general practice. Eur Arch Psychiatry Clin Neurosci 252, 99–104, 2002

  24. BACKHAUS, J., JUNGHANNS, K., BROOCKS, A., RIEMANN, D., HOHAGEN, F.: Test- retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia. Journal of Psychosomatic Research 53, 737–740, 2002

  25. BROOCKS, A., BANDELOW, B., KOCH, K., BARTMANN, U., KINKELBUR, J., SCHWEIGER, U., HOHAGEN, F., HAJAK, G.: Smoking Modulates Neuroendocrine Responses to Ipsapirone in Patients with Panic Disorder. Neuropsychopharmacology 27, 270–278, 2002

  26. PETER, H., HAND, I., HOHAGEN, F., KOENIG, A., MINDERMANN, O., OEDER, F., WITTICH, M.: Serum Cholesterol Level Comparison: Control Subjects, Anxiety Disorder Patients, and Obsessive-Compulsive Disorder Patients. Can J Psychiatry 47, 557–561, 2002

  27. RIEMANN, D., VODERHOLZER, U., COHRS, S., RODENBECK, A., HAJAK, G., RÜTHER, E., WIEGAND, M.H., LAAKMANN, G., BAGHAI, T., FISCHER, W., HOFFMANN, M., HOHAGEN, F., MAYER, G., BERGER, M.: Trimipramine in Primary Insomnia: Results of a Polysomnographic Double-Blind Controlled Study. Pharmacopsychiatry 35, 165–174, 2002

  28. FEIGE, B., VODERHOLZER, U., RIEMANN, D., DITTMANN, R., HOHAGEN, F., BERGER, M.: Fluoxetine and Sleep EEG: Effects of a Single Dose, Subchronic Treatment, and Discontinuation in Healthy Subjects. Neuropsychopharmacology 26, 246–258, 2002

  29. KÄPPLER, C., HOHAGEN, F.: Psychosocial aspects of insomnia – results of a study in general practice. Eur Arch Psychiatry Clin Neurosci 253, 49-52 (2003)

  30. HOHAGEN, F., STIEGLITZ, R.D., BOHUS, M., CASPAR, F., BERGER, M.: Psycho- therapie. In: BERGER, M. (Hrsg.) Psychische Erkrankungen (Neuauflage von Psychiatrie und Psychotherapie) Urban & Fischer, München, Jena, 161-251, 2003

  31. KUELZ, A.K., HOHAGEN, F., VODERHOLZER, U.: Neuropsychological performance in obsessive-compulsive disorder: a critical review Biological Psychology 65, 185-236 (2004)

  32. GANN, H., FEIGE, B., CLOOT, O. van WASEN, H., ZINZGRAF, D., HOHAGEN, F., RIEMANN, D.: Polysomnography During Withdrawal with Clomethiazole or Placebo in Alcohol Dependent Patients – A Double-Blind and Randomized Study Pharmacopsychiatry 37, 228-235 (2004)

  33. VODERHOLZER, U., HOHAGEN, F., KLEIN, T., JUNGNICKEL, J., KIRSCHBAUM, C., BERGER, M., RIEMANN, D.: Impact of Sleep Deprivation and Subsequent Recovery Sleep on Cortisol in Unmedicated Depressed Patients Am J Psychiatry 161, 1404-1410 (2004)

  34. BACKHAUS, J., JUNGHANNS, K., HOHAGEN, F.: Sleep disturbances are correlated with decreased morning awakening salivary cortisol Psychoneuroendocrinology 29, 1184-1191 (2004)

  35. LAUTERBACH, E., AHRENS, B., FELBER, W., MÜLLER-OERLINGHAUSEN, B., KILB, B., BISCHOF, G., HEUSER, I., WERNER, P., HAWALLEK, B., MAIER, W., LEWITZKA, U., POGARELL, O., HEGERL, U., BRONISCH, T., RICHTER, K., NIKLEWSKI, G., BROOCKS, A., HOHAGEN, F.: Suicide Prevention by Lithium (SUPLI) – Challenges of a Multi-center Prospective Study Archives of Suicide Research 9, 27-34 (2005)

  36. BRONISCH, T., BRUNNER; J., BONDY, B., RUJESCU, D., BISCHOF, G., HEUSER; I., MÜLLER-OERLINGHAUSEN, B., HAWELLEK, B., MAIER, W., RAO, M.L., FELBER, W., LWEITZKA, Z., OEHLER, J., BROOCKS, A., HOHAGEN, F., LAUTERBACH, E.: A A Multicenter Study about Neurobiology of Suicidal Behavior: Design, Development, and Preliminary Results Archives of Suicide Research 9, 19-26 (2005)

  37. KORDON, A., KAHL, K.G., BROOCKS, A., VODERHOLZER, U., RASCHE-RÄUCHLE, H., HOHAGEN, F.: Clinical outcome in patients with obsessive-compulsive disorder after discontinuation of SRI treatment: results from a two-year follow-up Eur Arch Psychiatry Clin Neurosci 255: 48-50 (2005)

  38. KAHL, K.G., BESTER, M., GREGGERSEN, W., RUDOLF, S., DIBBELT, L., STOECKELHUBER, B., GEHL, H.-B., SIPOS, V., HOHAGEN, F., SCHWEIGER, U.: Visceral Fat Deposition and Insulin Sensitivity in Depressed Woman With and Without Cormorbid Borderline Personality Disorder Psychosomatic Medicine 67, 407-412 (2005)

  39. KAHL, K.G., RUDOLF, S., DIBBELT, L, STOECKELHUBER, B., GEHL, H.-B., HOHAGEN, F., SCHWEIGER, U.: Decreased osteoprotegerin and increased bone turnover in young female patients with major depressive disorder and a lifetime history of anorexia nervosa Osteoporos Int 16, 424-429 (2005)

  40. KAHL, K.G., RUDOLF, S., STOECKELHUBER, B., DIBBELT, L., GEHL, H.-B., MAKRHOF, K., HOHAGEN, F., SCHWEIGER, U.: Bone Mineral Density, Markers of Bone Turnover and Cytokines in Young Women With Borderline Personality Disorder With and Without Comorbid Major Depressive Disorder Am J Psychiatry 162, 162-168 (2005)

  41. GANN, H., HARTIG, K., FEIGE, B., BRUECK, R., HOHAGEN, F., WESKE, G., van CALKER, D., RIEMANN, D.: The effects of clomethiazole on polysomnographically recorded sleep in healthy subjects Eur Arch Psychiatry Clin Neurosci 255, 284-290 (2005)

  42. LAUTERBACH, E., BRUNNER, J., HAWALLEK, B., LEWITZKA, U., ISING, M., BONDY, B., RAO, M.-L., FRAHNERT, C., RUJESCU, D., MÜLLER-OERLINGHAUSEN, B., SCHLEY, J., HEUSER, I., MAIER, W., HOHAGEN, F., FELBER, W., BRONISCH, T.: Platelet 5-HT2A receptor binding and tryptophan availability in depression are not associated with recent history of suicide attempts but with personality traits characteristic for suicidal behaviour Journal of Affective Disorders 91, 57-62 (2006)

  43. FEIGE, B., GANN, H., BRUECK, R., HORNYAK, M., LITSCH, S., HOHAGEN, F., RIEMANN, D.: Effects of Alcohol on Polysomnographically Recorded Sleep in Healthy Subjects. Alcohol Clin Exp Res. Vol 30, No 9, 1527-1537 (2006)

  44. DYBEK, I., BISCHOF, G., GROTHUES, J., REINHARDT, S., MEYER, C., HAPKE, U., JOHN, U., BROOCKS, A., HOHAGEN, F., RUMPF, H.J.: The Reliability and Validity of the Alcohol Use Disorders Identification Test (AUDIT) in a German General Practice Population Sample Journal of Studies on Alcohol, 473-481 (2006)

  45. HARMSEN, H., BISCHOF, G., BROOCKS, A., HOHAGEN, F., RUMPF, J.-J.: The relationship between impaired decision-making, sensation seeking and Readiness to change in cigarette smoke Addictive Behaviours 31, 581-592 (2006)

  46. KÜHN, M., EHLERT, U., RUMPF, H.J., BACKHAUS, J., HOHAGEN, F., BROOCKS, A.: Onset and maintenance of psychiatric disorders after serious accidents Eur Arch Psychiatry Clin Neurosci 256, 497 – 503 (2006)

  47. BACKHAUS, J., JUNGHANNS, K., BORN, J., HOHAUS, K., FAASCH, F., HOHAGEN, F.: Impaired Declarative Memory Consolidation During Sleep in Patients With Primary Insomnia: Influence of Sleep Architecture and Nocturnal Cortisol Release Biol Psychiatry 60, 1324 – 1330 (2006)

  48. SPENGLER, D., TRILLENBERG, P., SPRENGER, A., NAGEL, M., KORDON, A., JUNGHANNS, K., HEIDE, W., AROLT, V., HOHAGEN, F., LENCER, R.: Evidence from increased anticipation of predictive saccades for a dysfunction of fronto-striatal circuits in obsessive-compulsive disorder Psychiatry Research 143, 77 – 88 (2006)

  49. BACKHAUS, J., BORN, J., HOECKESFELD, R., FOKUHL, S., HOHAGEN, F., JUNGHANNS, K.: Midlife decline in declarative memory consolidation is correlated with a decline in slow wave sleep. Neurobiology of Learning & Memory, 1-6 (2007)

  50. VODERHOLZER, U., RIEMANN, D., HUWIG-POPPE, C., KUELZ, A., KORDON, A., BRUESTLE, K., BERGER, M., HOHAGEN, F.: Sleep in obsessive compulsive disorder. Eur Arch Psychiatry Clin Neurosci 257, 173 – 182 (2007)

  51. BACKHAUS, J., HOECKESFELD, R., BORN, J., HOHAGEN, F., JUNGHANNS, K.: Immediate as well as delayed post learning sleep but not wakefulness enhances declarative memory consolidation in childen. Neurobiology of Learning & Memory 89, 76 - 80 (2007)

  52. ZUROWSKI, B., WAHL, K., HOHAGEN, F., KORDON. A.: Symptom remission in OCD after discontinuation of pharmacotherapy with fluoxetine: A case for looking beyond serotonin. Progress in Neuro-Psychopharmacology & Biological Psychiatry 31, 959 – 960 (2007)