The Selfish Brain Clinical Research Group 
Recent Publications:
Olaf Jöhren, Assistant Professor of Pharmacology
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Luebeck, Germany

  1. Voigt JP, Raasch W, Hörtnagl H, Bader M, Fink H, Jöhren O (2007) Changes in brain serotonin satiety system in transgenic rats lacking brain angiotensinogen. Journal of Neuroendocrinology, in press

  2. Jöhren O, Dendorfer, A., Dominiak P, Raasch W (2007) Gene expression of mineralocorticoid and glucocorticoid receptors in the limbic system is related to type-2 like diabetes in leptin-resistant rats. Brain Research, 1184, 160-167

  3. Müller H, Schweitzer N, Jöhren O, Dominiak P, Raasch W (2007) Angiotensin II stimulates the reactivity of the pituitary-adrenal-axis in leptin resistant Zucker rats, thereby influencing the glucose utilization. American Journal of Physiology – Endocrinology and Metabolism 293, E802–E810

  4. Heidbreder M, Qadri F, Jöhren O, Dendorfer A, Depping R, Fröhlich F; Wagner KF, Dominiak P (2007) Non-hypoxic induction of HIF-3α by 2-deoxy-D-glucose and insulin. Biochemical and Biophysical Research Communications 352, 437–443

  5. Jöhren O, Gremmels JAF, Qadri F, Dendorfer A, Dominiak P (2006) Adrenal expression of orexin receptor subtypes is differentially regulated in experimental streptozotocin induced type-1 diabetes. Peptides 27, 2764–2769

  6. Raasch W, Wittmershaus C, Dendorfer A, Voges I, Pahlke F, Dodt C, Dominiak P, Jöhren O (2006) Angiotensin II inhibition reduces stress sensitivity of hypothalamo-pituitary-adrenal axis in SHR. Endocrinology 147, 3539–3546

  7. Patzak A, Bontscho J, Lai E, Kupsch E, Skalweit A, Richter CM, Zimmermann M, Thöne-Reineke C, Jöhren O, Godes M, Steege A, Hocher B (2005) Angiotensin II sensitivity of afferent glomerular arterioles in endothelin-1 transgenic mice. Nephrology Dialysis Transplantation 20, 2681-2689

  8. Häuser W, Sassmann A, Qadri F, Jöhren O, Dominiak P (2005) Expression of nitric oxide synthase isoforms in hypothalamo-pituitary-adrenal axis during the development of spontaneous hypertension in rats. Molecular Brain Research 138, 198-204

  9. Dendorfer A, Heidbreder M, Hellwig-Bürgel T, Jöhren O, Qadri F, Peter Dominiak P (2005) Deferoxamine induces prolonged cardiac preconditioning via accumulation of oxygen radicals. Free Radical Biology and Medicine 38, 117-124

  10. Qadri F, Stark E, Häuser W, Jöhren O, Dendorfer A, Dominiak P (2004) Expression of Kinin Receptor mRNA in the HPA Axis of Type 1 and Type 2 Diabetic Rats. International Immunopharmacology 4, 571-576

  11. Raasch W, Jöhren O, Schwartz S, Gieselberg A, Dominiak P (2004) Combined blockade of AT1-receptors and ACE synergistically potentiate antihypertensive effects in SHR. Journal of Hypertension 22, 611-618

  12. Heidbreder M, Fröhlich F, Jöhren O, Dendorfer A, Qadri F, Dominiak P (2003) Hypoxia rapidly activates HIF-3α mRNA expression. FASEB Journal 17, 1541-1543

  13. Jöhren O, Brüggemann N, Dendorfer A, Dominiak P (2003) Gonadal steroids differentially regulate the messenger ribonucleic acid expression of pituitary orexin type 1 receptors and adrenal orexin type 2 receptors. Endocrinology 144, 1219-1225

  14. Jöhren O, Golsch C, Dendorfer A, Qadri F, Häuser W, Dominiak P (2003) Differential expression of AT1 receptors in the pituitary and adrenal gland of SHR and WKY. Hypertension 41, 984-990

  15. Qadri F, Schwartz EC, Häuser W, Jöhren O, Müller-Esterl W, Dominiak P (2003) Kinin B2 receptor expression in the hypothalamo-pituitary-adrenal axis of spontaneously hypertensive rats. International Immunopharmacology 3, 285-292

  16. Jöhren O, Neidert SJ, Kummer M, Dominiak P (2002) Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus. Peptides 23, 1177-1180

  17. Leong DS, Terron JA, Falcon-Neri A, Armando I, Ito T, Jöhren O, Tonelli L, Hoe KL, Saavedra JM (2002). Restraint stress modulates brain, pituitary and adrenal expression of angiotensin II AT1A, AT1B and AT2 receptors. Neuroendocrinology 75, 227-240

  18. Qadri F, Häuser W, Jöhren O, Dominiak P (2002) Kinin B1 and B2 receptor mRNA expression in the hypothalamus of spontaneously hypertensive rat. Canadian Journal of Physiology and Pharmacology 80, 258-263

  19. Jöhren O, Neidert SJ, Kummer M, Dendorfer A, Dominiak P (2001) Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rat. Endocrinology 142, 3324-3331

  20. Kummer M, Neidert SJ, Jöhren O, Dominiak P (2001) Orexin (hypocretin) gene expression in rat ependymal cells. NeuroReport 12, 2117-2120

  21. Saavedra JM, Armando I, Terron JA, Falcon-Neri A, Jöhren O, Häuser W, Inagami T (2001) Increased AT1 receptors in adrenal gland of AT2 receptor gene-disrupted mice. Regulatory Peptides 102, 41-47

  22. Saavedra JM, Häuser W, Ciuffo G, Egidy G, Hoe KL, Jöhren O, Sembonmatsu T, Inagami T, Armando I (2001) Increased AT1 receptor expression and mRNA in kidney glomeruli of AT2 receptor gene disrupted mice. American Journal of Physiology - Renal Physiology 280, F71-F78

  23. Tonelli L, Jöhren O, Hoe KL, Häuser W, Saavedra JM (2000) Gerbil angiotensin II AT1 receptors are highly expressed in the hippocampus and cerebral cortex during postnatal development. Neuroscience 95, 981-991

  24. Häuser W, Jöhren O, De Oliveira AM, Shibata S, Saavedra JM (1999) Ischemia-induced neuronal cell loss is associated with loss of atypical angiotensin type-1 receptor expression in the gerbil hippocampal formation. Brain Research 817, 34-44

  25. Hilbers U, Peters J, Bornstein SR, Correa FMA, Jöhren O, Saavedra JM, Ehrhart-Bornstein M (1999) A local renin-angiotensin system is involved in K+-induced aldosterone secretion from human adrenocortical NCI-H295 cells. Hypertension 33, 1025-1030

  26. Häuser W, Jöhren O, Saavedra JM (1998) Characterization and distribution of angiotensin II receptor subtypes in the mouse brain. European Journal of Pharmacology 348, 101-114

  27. Jöhren O, Häuser W, Saavedra JM (1998) Chemical lesion of the inferior olive reduces [125I]Sarcosine1-Angiotensin II binding to AT2 receptors in the cerebellar cortex of young rats. Brain Research 793, 176 186

  28. Moriuchi R, Shibata S, Himeno A, Jöhren O, Hoe KL, Saavedra JM (1998) Molecular cloning and pharmacological characterization of an atypical gerbil angiotensin II type-1 receptor and its mRNA expression in brain and peripheral tissues. Molecular Brain Research 60, 234-246

  29. Nishimura Y, Xu T, Jöhren O, Häuser W, Saavedra JM (1998) The angiotensin AT1 receptor antagonist CV-11974 regulates cerebral blood flow and brain angiotensin AT1 receptor expression. Basic Research in Cardiology 93 (S2), 63-68