THE SELFISH BRAIN THEORY
The Selfish Brain Clinical Research Group
www.selfish-brain.net 
Recent Publications:
Luc Pellerin, PhD, Associate Prof. of Physiology
Département de Physiologie, University of Lausanne, Switzerland

  1. Insulin and IGF-1 enhance the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin pathway. J. Chenal, K. Pierre and L. Pellerin, Eur. J. Neurosci. 27:53-65, 2008.

  2. Differential energetic response of brain vs. skeletal muscle upon glycemic variations in healthy humans. K.M. Oltmanns, U.H. Melchert, H.G. Scholand-Engler, M.C. Howitz, B. Schultes, U. Schweiger, F. Hohagen, J. Born, A. Peters and L. Pellerin, Am. J. Physiol. 294 :R12-R16, 2008.

  3. Activity-dependent regulation of energy metabolism by astrocytes: an update. L. Pellerin, A.K. Bouzier-Sore, A. Aubert, S. Serres, M. Merle, R. Costalat and P.J. Magistretti, Glia 55:1251-1262, 2007.

  4. Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice. K. Pierre, A. Parent, P.Y. Jayet, A.P. Halestrap, U. Scherrer and L. Pellerin, J. Physiol. 583 :469-486, 2007.

  5. Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase. J.D. Laughton, P. Bittar, Y. Charnay, L. Pellerin, E. Kovari, P.J. Magistretti and C. Bouras, BMC Neurosci. 8:35, 2007.

  6. Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by a translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway. J. Chenal and L. Pellerin, J. Neurochem. 102: 389-397, 2007.

  7. A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmetalized energy metabolism. A. Aubert, L. Pellerin, P.J. Magistretti and R. Costalat. Proc. Natl. Acad. Sci. USA 104:4188-4193, 2007.

  8. Causes of obesity: Looking beyond the hypothalamus. A. Peters, L. Pellerin, M.F. Dallman, K.M. Oltmanns, U. Schweiger, J. Born and H.L. Fehm. Prog. Neurobiol. 81:61-88, 2007.

  9. Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study. A.-K. Bouzier-Sore, P.Voisin, V. Bouchaud, E. Bezancon, J.-M. Franconi and L. Pellerin, Eur. J. Neurosci. 24:1687-1694, 2006.

  10. Metabolic activation pattern of distinct hippocampal subregions during spatial learning and memory retrieval. J. Ros, L. Pellerin, F. Magara, J. Dauguet, F. Schenk and P.J. Magistretti, J. Cereb. Blood Flow Metab. 26:468-477, 2006.

  11. Expression of the monocarboxylate transporter MCT1 in the adult human brain cortex. O. Chiry, L. Pellerin, F. Monnet-Tschudi, W.N. Fishbein, N. Merezhinskaya, P.J. Magistretti and S. Clarke, Brain Res. 1070:65-70, 2006.

  12. Is lactate a major energy substrate for neurons? R. Costalat, A. Aubert, P.J. Magistretti, L. Pellerin, Med. Sci. (Paris) 22:356-357, 2006.

  13. Brain lactate kinetics: modeling evidence for neuronal lactate uptake upon activation. A. Aubert, R. Costalat, P.J. Magistretti and L. Pellerin, Proc. Natl. Acad. Sci. USA 102:16448-16453, 2005.

  14. Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor modulators. L. Pellerin and P.J. Magistretti, J. Neurochem. 92:668-677, 2005.

  15. Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain. L. Pellerin, L.H. Bergersen, A.P. Halestrap and K. Pierre, J, Neurosci. Res. 79:55-64, 2005.

  16. Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking. L.H. Bergersen, P.J. Magistretti and L. Pellerin, Cereb. Cortex 15 :361-370, 2005.

  17. Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity. S.B. Tekkök, A.M. Brown, R. Westenbroek, L. Pellerin and B.R. Ransom, J. Neurosci. Res. 81:644-652, 2005.

  18. Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. M.G. Zurich, S. Lengacher, O. Braissant, F. Tschudi-Monnet, L. Pellerin and P. Honegger, Neuroscience 134:771-782, 2005.

  19. Monocarboxylate transporters in the central nervous system: distribution, regulation and function. K. Pierre and L. Pellerin, J. Neurochem. 94:1-14, 2005.

  20. How astrocytes feed hungry neurons. L. Pellerin, Mol. Neurobiol. 39:59-72, 2005.

  21. Let there be (NADH) light. L. Pellerin and P.J. Magistretti, Science 305:50-52, 2004.

  22. Dual gene, dual-cell type therapy against an excitotoxic insult by bolstering neuroenergetics. T.M. Bliss, M. Ip, E. Cheng, M. Minami, L. Pellerin, P.J. Magistretti and R.M. Sapolsky, J. Neurosci. 24:6202-6208, 2004.

  23. Quantitative RT-PCR analysis of uncoupling protein isoforms in mouse brain cortex : methodological optimization and comparison of expression with brown adipose tissue and skeletal muscle. S. Lengacher, P.J. Magistretti and L. Pellerin, J. Cereb. Blood Flow Metab. 24:780-788, 2004.

  24. Empiricism and rationalism : two paths toward the same goal. L. Pellerin and P.J. Magistretti, J. Cereb Blood Flow Metab. 24:1240-1241, 2004.

  25. The selfish brain : competition for energy resources. A. Peters, U. Schweiger, L. Pellerin, C. Hubold, K.M. Oltmanns, M. Conrad, B. Schultes, J. Born and H.L. Fehm, Neurosci. Biobehav. Rev. 28:143-180, 2004.

  26. Neuroenergetics: calling upon astrocytes to satisfy hungry neurons. L. Pellerin and P.J. Magistretti, Neuroscientist 10:53-62, 2004.

  27. Early acquisition of typical metabolic features upon differentiation of mouse neural stem cells into astrocytes. J.-F. Brunet, L. Grollimund, J.-Y. Chatton, S. Lengacher, P.J. Magistretti, J.-G. Villemure and L. Pellerin, Glia 46:8-17, 2004.

  28. Glucocorticoids modulate neurotransmitter-induced glycogen metabolism in cultured cortical astrocytes. I. Allaman, L. Pellerin and P.J. Magistretti, J. Neurochem. 88:900-908, 2004.

  29. Immunocytochemical expression of monocarboxylate transporters in the human visual cortex at midgestation. L. Fayol, O. Baud, A. Monier, L. Pellerin, P.J. Magistretti, P. Evrard and C. Verney, Dev. Brain Res. 148:69-76, 2004.

  30. Lactate is a preferential oxidative energy substrate over glucose for neurons in culture. A.-K. Bouzier-Sore, P. Voisin, P. Canioni, P.J. Magistretti and L. Pellerin, J. Cereb. Blood Flow Metab. 23:1298-1306, 2003.

  31. Cryopreservation of human brain tissue allowing timely production of viable adult human brain cells for autologous transplantation. J.-F. Brunet, L. Pellerin, P.J. Magistretti and J.-G. Villemure, Cryobiology 47:179-183, 2003.

  32. GABA uptake into astrocytes is not associated with significant metabolic cost: implications for brain imaging of inhibitory transmission. J.-Y. Chatton, L. Pellerin and P.J. Magistretti, Proc. Natl. Acad Sci. USA 100:12456-12461, 2003.

  33. Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex. B. Voutsinos-Porche, G. Bonvento, K. Tanaka, P. Steiner, E. Welker, J.-Y. Chatton, P.J. Magistretti and L. Pellerin, Neuron 37:275-286, 2003.

  34. A2b receptor activation promotes glycogen synthesis in astrocytes through modulation of gene expression. I. Allaman, S. Lengacher, P.J. Magistretti and L. Pellerin, Am. J. Physiol. Cell Physiol. 284:C696-C704, 2003.

  35. Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures. R. Debernardi, K. Pierre, S. Lengacher, P.J. Magistretti and L. Pellerin, J. Neurosci. Res. 73:141-155, 2003.

  36. Noradrenaline enhances MCT2 expression in cultured mouse cortical neurons via a translational regulation. K. Pierre, R. Debernardi, P.J. Magistretti and L. Pellerin, J. Neurochem. 86:1468-1476, 2003.

  37. Developmental and hormonal regulation of the monocarboxylate transporter 2 (MCT2) expression in the mouse germ cells. F. Boussouar, C. Mauduit, E. Tabone, L. Pellerin, P.J. Magistretti and M. Benahmed, Biol. Reprod. 69:1069-1078, 2003.

  38. Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain. O. Baud, L. Fayol, P. Gressens, L. Pellerin, P.J. Magistretti, P. Evrard and C. Verney, J. Comp Neurol. 465:445-454, 2003.

  39. Food for thoughts: challenging the dogmas. L. Pellerin and P.J. Magistretti, J. Cereb. Blood Flow Metab. 23:1282-1286, 2003.

  40. How to balance the brain energy budget while spending glucose differently. L. Pellerin and P.J. Magistretti, J. Physiol. (Lond), 546:325, 2003.

  41. Lactate as a pivotal element in neuron-glia metabolic cooperation. L. Pellerin, Neurochem. Int., 43:331-338, 2003.

  42. Similar perisynaptic glial localization for the Na+,K+-ATPase α2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex. N. Cholet, L. Pellerin, P.J. Magistretti and E. Hamel, Cerebral Cortex 21:404-412, 2002.

  43. MCT2 is a major neuronal monocarboxylate transporters in the adult mouse brain. K. Pierre, P.J. Magistretti and L. Pellerin, J. Cereb. Blood Flow Metab. 22:586-595, 2002.

  44. Long-term modulation of glucose utilization by IL-1α and TNFα in astrocytes: Na+ pump activity as a potential target via distinct signaling mechanisms. C. Véga, L. Pellerin, R. Dantzer and P.J. Magistretti, Glia 39:10-18, 2002.

  45. A novel method for in vitro production of human glial-like cells from neurosurgical resection tissue. J.-F. Brunet, L. Pellerin, Y. Arsenijevic, P. Magistretti and Jean-Guy Villemure, Lab. Invest. 82:1-4, 2002.

  46. Role of neuron-glia interaction in the regulation of brain glucose utilization. L. Pellerin, G. Bonvento, J.Y. Chatton, K. Pierre and P.J. Magistretti, Diabetes Nutr. Metab., 15:268-273, 2002.

  47. Does glutamate image your thoughts? G. Bonvento, N. Sibson and L. Pellerin, Trends Neurosci., 25:359-364, 2002.

  48. Feeding active neurons: (Re)Emergence of a nursing role for astrocytes. A.-K. Bouzier-Sore, M. Merle, P.J. Magistretti and L. Pellerin, J. Physiol. (Paris), 96:273-282, 2002.

  49. Astrocytes as a predominant cellular site of 99mTc-HMPAO retention. S. Zerarka, L. Pellerin, D.O. Slosman and P.J. Magistretti, J. Cereb. Blood Flow Metab. 21: 456-468, 2001.

  50. Local injection of antisense oligonucleotides targeted to the glial glutamate transporter GLAST decreases the metabolic response to somatosensory activation. N. Cholet, L. Pellerin, E. Welker, P. Lacombe, J. Seylaz, P.J. Magistretti and G. Bonvento, J. Cereb. Blood Flow Metab. 21:404-412, 2001.

  51. What you see is what you think – or is it? L. Pellerin, N.R. Sibson, F. Hyder and N. Hadjikhani, Trends Neurosci., 24:71-72, 2001.

  52. Brain energy metabolism in Alzheimer's disease: 99mTc-HMPAO SPECT imaging during verbal fluency and role of astrocytes in the cellular mechanism of 99mTc-HMPAO retention. D.O. Slosman, C. Ludwig, S. Zerarka, L. Pellerin, C. Chicherio, A. de Ribaupierre, J.M. Annoni, C. Bouras, F. Herrmann, J.P. Michel, E. Giacobini, P.J. Magistretti, Brain Res. Rev., 36:230-240, 2001.

  53. Cell-specific localization of monocarboxylate transporters MCT1 and MCT2 revealed by double immunohistochemical labeling and confocal microscopy in the adult mouse brain. K. Pierre, L. Pellerin, B.M. Riederer and P.J. Magistretti, Neuroscience 100:617-627, 2000.

  54. Protein Targeting to Glycogen (PTG) mRNA expression is stimulated by noradrenaline inmouse cortical astrocytes. I. Allaman, L. Pellerin and P. J. Magistretti, Glia 30:382-391, 2000.

  55. Differential messenger RNA distribution for lactate dehydrogenase LDH-1 and LDH-5 isoforms in the rat brain. J.D. Laughton, Y. Charnay, B. Belloir, L. Pellerin, P.J. Magistretti and C. Bouras, Neuroscience 96:619-625, 2000.

  56. Deep hypothermia and rewarming alters glutamate levels and glycogen content in cultured astrocytes. B. Bissonnette, L. Pellerin, P. Ravussin, V. B. Daven and P. J. Magistretti, Anesthesiology 91:1763-1769, 1999.

  57. Trans-inhibition of glutamate transport prevents excitatory amino acid-induced glycolysis in astrocytes. R. Debernardi, P.J. Magistretti and L. Pellerin, Brain Res. 850:38-45, 1999.

  58. Focal cerebral ischaemia induces a decrease in activity and a shift in ouabain affinity of Na+, K+-ATPase isoforms without modifications in mRNA and protein expression. I. Jamme, O. Barbey, P. Trouvé, D. Charlemagne, J.-M. Maixent, E.T. MacKenzie, L. Pellerin and A. Nouvelot, Brain Res. 819:132-142, 1999.

  59. Energy on demand. P.J. Magistretti, L. Pellerin, D.L. Rothman and R.G. Shulman, Science, 283: 496-497, 1999.

  60. Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging. P.J. Magistretti and L. Pellerin, Phil. Trans. Roy. Soc. (Lond) , 354:1155-1163, 1999.

  61. Astrocytes couple synaptic activity to glucose utilization in the brain. P.J. Magistretti and L. Pellerin, News Physiol. Sci., 14:177-182, 1999.

  62. Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. L. Pellerin, G. Pellegri, P.G. Bittar, Y. Charnay, C. Bouras, J.-L. Martin, N. Stella and P.J. Magistretti, Dev. Neurosci. 20:291-299, 1998.

  63. Expression of monocarboxylate transporter mRNAs in mouse brain: Support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain. L. Pellerin, G. Pellegri, J.-L. Martin and P.J. Magistretti, Proc. Natl. Acad. Sci. USA, 95:3990-3995, 1998.