THE SELFISH BRAIN THEORY
selfish-brain
The Selfish Brain Clinical Research Group
www.selfish-brain.net 


University of Luebeck, Germany

Project-related publications from 2004 to 2010

Project:

Z"Central Glucose Feedback" and "Brain Corticosteroid Feedback" in the Energy Push-Pull Principle

  • Hitze B, Hubold C, van Dyken R, Schlichting K, Lehnert H, Entringer S, Peters A 2010 How the Selfish Brain Organizes its 'Supply and Demand'. Front Neuroenergetics 2:doi: 10.3389/fnene.2010.00007

  • Peters A, Langemann D 2010 Stress and eating behavior. 2 ed.; 13 (doi:10.3410/B2-13)

  • Peters A, Hitze B, Langemann D, Bosy-Westphal A, Mueller MJ 2010 Brain size, body size, and longevity.; doi:10.1038/ijo.2010.65

  • van Dyken R, Hubold C, Meier S, Hitze B, Marxsen A, Oltmanns KM, Schweiger U, Lehnert H, Pellerin L, Peters A 2010 Low plasma lactate concentrations as a biomarker of an incompetent brain pull: a risk factor for weight gain in type 2 diabetes patients.; doi:10.1016/j.psychneuen.2010.02.016

  • Klement J, Hubold C, Hallschmid M, Loeck C, Oltmanns KM, Lehnert H, Born J, Peters A 2009 Effects of glucose infusion on neuroendocrine and cognitive parameters in Addison disease. Metabolism 58:1825-1831

  • Klement J, Pais I, Hallschmid M, Hubold C, Knispel A, Oltmanns KM, Schultes B, Born J, Peters A 2009 Blocking AMPA receptor signalling by caroverine infusion does not affect counter-regulation of hypoglycaemia in healthy men. Diabetologia 52:1192-1196

  • Langemann D, Pellerin L, Peters A. Making sense of AMPA receptor trafficking by modeling molecular mechanisms of synaptic plasticity. Brain Res 2008 (Epub ahead of print)

  • Peters A, Conrad M, Hubold C, Schweiger U, Fischer B, Fehm HL. The principle of homeostasis in the hypothalamus-pituitary-adrenal system: new insight from positive feedback. Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R83-98.

  • Peters A, Pellerin L, Dallman MF, Oltmanns KM, Schweiger U, Born J, Fehm HL. Causes of obesity: looking beyond the hypothalamus.Prog Neurobiol. 2007 Feb;81(2):61-88.

  • Langeman-D. Selfish-brain theory: mathematical challenges in the top-down analysis of metabolic supply chains. CRPIT 2007;83: 39-49

  • Hubold C, Oltmanns KM, Schultes B, Jelkmann W, Born J, Fehm HL, Schweiger U, Peters A. High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetes.Int J Obes (Lond). 2006 Sep;30(9):1356-61

  • Oltmanns KM, Dodt B, Schultes B.; Raspe HH, Schweiger U, Born J, Fehm HL, Peters A. Cortisol correlates with metabolic disturbances in a population study of type 2 diabetic patients.Eur J Endocrinol 2006 Feb;154:325-331

B1Explorations into the Molecular Basis of the Pull Principle in the Astrocyte-Neuron Shuttle with NMR

  • Pellerin L, Bouzier-Sore AK, Aubert A, Serres S, Merle M, Costalat R, Magistretti PJ. Activity-dependent regulation of energy metabolism by astrocytes: an update. Glia. 2007 Sep;55(12):1251-62.

  • Pierre K, Parent A, Jayet PY, Halestrap AP, Scherrer U, Pellerin L. Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice. J Physiol. 2007 Sep 1;583(Pt 2):469-86.

  • Bouzier-Sore AK, Voisin P, Bouchaud V, Bezancon E, Franconi JM, Pellerin L. Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study. Eur J Neurosci. 2006 Sep;24(6):1687-94.

  • Aubert A, Costalat R, Magistretti PJ, Pellerin L. Brain lactate kinetics: Modeling evidence for neuronal lactate uptake uponactivation. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16448-53.

  • Rademacher C, Shoemaker GK, Kim HS, Zheng RB, Taha H, Liu C, Nacario RC, Schriemer DC, Klassen JS, Peters T, Lowary TL. Ligand specificity of CS-35, a monoclonal antibody that recognizes mycobacterial lipoarabinomannan: a model system for oligofuranoside-protein recognition. J Am Chem Soc. 2007 Aug 29;129(34):10489-502.

  • Angulo J, Langpap B, Blume A, Biet T, Meyer B, Krishna NR, Peters H, Palcic MM, Peters T. Blood group B galactosyltransferase: insights into substrate binding from NMR experiments. J Am Chem Soc. 2006 Oct 18;128(41):13529-38.

B2Cerebral Need and Allocative Response

  • Oltmanns KM, Melchert UH, Scholand-Engler HG, Howitz MC, Schultes B, Schweiger U, Hohagen F, Born J, Peters A, Pellerin L. Differential energetic response of brain vs. skeletal muscle upon glycemic variations in healthy humans.Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R12-6.

  • Benedict C, Ghio AJ, Gehring H, Schultes B, Peters A, Oltmanns KM. Transient hypoxia and downregulation of circulating prohepcidin concentrations in healthy young men. Haematologica. 2007 Jan;92(1):125-6.

  • Oltmanns KM, Gehring H, Rudolf S, Schultes B, Schweiger U, Born J, Fehm HL, Peters A. Persistent suppression of resting energy expenditure after acute hypoxia. Metabolism. 2006 May;55(5):669-75.

  • Oltmanns KM, Gehring H, Rudolf S, Schultes B, Hackenberg C, Schweiger U, Born J, Fehm HL, Peters A. Acute hypoxia decreases plasma VEGF concentration in healthy humans. Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E434-9.

  • Oltmanns KM, Gehring H, Rudolf S, Schultes B, Rook S, Schweiger U, Born J, Fehm HL, Peters A. Hypoxia causes glucose intolerance in humans. Am J Respir Crit Care Med. 2004 Jun 1;169(11):1231-7.

B3Assessment and Conditioning of Allocative and Ingestive Behavior

  • Schweiger U, Greggersen W, Rudolf S, Pusch M, Menzel T, Winn S, Hassfurth J, Fassbinder E, Kahl KG, Oltmanns KM, Hohagen F, Peters A. Disturbed glucose disposal in patients with major depression. Application of the glucose clamp technique. Psychosom Med 2008 (in press)

  • Kahl KG, Greggersen W, Rudolf S, Stoeckelhuber BM, Bergmann-Koester CU, Dibbelt L, Schweiger U. Bone mineral density, bone turnover, and osteoprotegerin in depressed women with and without borderline personality disorder. Psychosom Med. 2006 Sep-Oct;68(5):669-74.

  • Kahl KG, Bens S, Ziegler K, Rudolf S, Dibbelt L, Kordon A, Schweiger U. Cortisol, the cortisol-dehydroepiandrosterone ratio, and pro-inflammatory cytokines in patients with current major depressive disorder comorbid with borderline personality disorder.Biol Psychiatry. 2006 Apr 1;59(7):667-71.

  • Kahl KG, Bester M, Greggersen W, Rudolf S, Dibbelt L, Stoeckelhuber BM, Gehl HB, Sipos V, Hohagen F, Schweiger U. Visceral fat deposition and insulin sensitivity in depressed women with and without comorbid borderline personality disorder. Psychosom Med. 2005 May-Jun;67(3):407-12.

  • Kahl KG, Rudolf S, Stoeckelhuber BM, Dibbelt L, Gehl HB, Markhof K, Hohagen F, Schweiger U. Bone mineral density, markers of bone turnover, and cytokines in young women with borderline personality disorder with and without comorbid major depressive disorder. Am J Psychiatry. 2005 Jan;162(1):168-74.

  • Kahl KG, Rudolf S, Dibbelt L, Stoeckelhuber BM, Gehl HB, Hohagen F, Schweiger U. Decreased osteoprotegerin and increased bone turnover in young female patients with major depressive disorder and a lifetime history of anorexia nervosa. Osteoporos Int. 2005 Apr;16(4):424-9.

B4Metabolic Learning

  • Pais I, Hallschmid M, Jauch-Chara K, Schmid SM, Oltmanns KM, Peters A, Born J, Schultes B. Mood and cognitive functions during acute euglycaemia and mild hyperglycaemia in type 2 diabetic patients. Exp Clin Endocrinol Diabetes. 2007 Jan;115(1):42-6.

  • Schultes B, Kern W, Oltmanns K, Peters A, Gais S, Fehm HL, Born J. Differential adaptation of neurocognitive brain functions to recurrent hypoglycemia in healthy men. Psychoneuroendocrinology. 2005 Feb;30(2):149-61.

  • Schultes B, Jauch-Chara K, Gais S, Hallschmid M, Reiprich E, Kern W, Oltmanns KM, Peters A, Fehm HL, Born J. Defective awakening response to nocturnal hypoglycemia in patients with type 1 diabetes mellitus. PLoS Med. 2007 Feb;4(2):e69.

B5Anticipation of Ingestive Behavior

  • Hallschmid M, Benedict C, Schultes B, Born J, Kern W. Obese men respond to cognitive but not to catabolic brain insulin signaling. Int J Obes (Lond). 2007 Sep 11;

  • Hallschmid M, Smolnik R, McGregor G, Born J, Fehm HL. Overweight humans are resistant to the weight-reducing effects of melanocortin4-10. J Clin Endocrinol Metab. 2006 Feb;91(2):522-5.

  • Kern W, Benedict C, Schultes B, Plohr F, Moser A, Born J, Fehm HL, Hallschmid M. Low cerebrospinal fluid insulin levels in obese humans. Diabetologia. 2006 Nov;49(11):2790-2.

B6ATP-sensitive Potassium Channels in Neuronal Network

  • Steinkamp M, Li T, Fuellgraf H, Moser A. K(ATP)-dependent neurotransmitter release in the neuronal network of the rat caudate nucleus. Neurochem Int. 2007 Jan;50(1):159-63.

  • Mantovani M, Van Velthoven V, Fuellgraf H, Feuerstein TJ, Moser A. Neuronal electrical high frequency stimulation enhances GABA outflow from human neocortical slices. Neurochem Int. 2006 Sep;49(4):347-50.

B7Cellular Mechanisms to set the Pull Principle

  • Heidbreder M, Qadri F, Johren O, Dendorfer A, Depping R, Frohlich F, Wagner KF, Dominiak P. Non-hypoxic induction of HIF-3alpha by 2-deoxy-D-glucose and insulin. Biochem Biophys Res Commun. 2007 Jan 12;352(2):437-43.

  • Raasch W, Wittmershaus C, Dendorfer A, Voges I, Pahlke F, Dodt C, Dominiak P, Johren O. Angiotensin II inhibition reduces stress sensitivity of hypothalamo-pituitary-adrenal axis in spontaneously hypertensive rats. Endocrinology. 2006 Jul;147(7):3539-46.

  • Johren O, Dendorfer A, Dominiak P, Raasch W. Gene expression of mineralocorticoid and glucocorticoid receptors in the limbic system is related to type-2 like diabetes in leptin-resistant rats. Brain Res. 2007 Dec 12;1184:160-7.

B8HTLV-1-impaired Brain Metabolism

  • Mesters JR, Tan J, Hilgenfeld R. Viral enzymes. Curr Opin Struct Biol. 2006 Dec;16(6):776-86.

  • Mesters JR, Barinka C, Li W, Tsukamoto T, Majer P, Slusher BS, Konvalinka J, Hilgenfeld R. Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer. EMBO J. 2006 Mar 22;25(6):1375-84.